Parents often seek formulas that ease fussiness and gas in babies who may be lactose sensitive or have delicate tummies. This guide highlights five infant formulas designed to support easier digestion, with features like prebiotic blends, gentle protein profiles, and nutrients found in breast milk. Each option below is evaluated for how it may help reduce gas, spit-up, and discomfort, while still delivering complete nutrition for 0–12 months.
| Product | Brand | Notes |
|---|---|---|
| Similac 360 Total Care Sensitive Infant Formula for Fussiness & Gas Due to Lactose Sensitivity | Similac | 5 HMO prebiotics blend; supports gentle tummy; lactose sensitivity focus |
| Similac Sensitive Infant Formula for Fussiness & Gas Due to Lactose Sensitivity | Similac | Designed for fussiness and gas; DHA and lutein supports |
| ByHeart Infant Formula Powder for Infants 0-12 Months | ByHeart | Organic whole milk base; patented protein blend; closest-to-breast milk |
| Enfamil Gentlease Easy to Digest Baby Formula | Enfamil | Gentle proteins; clinically shown to ease fussiness and gas |
| Enfamil NeuroPro Gentlease | Enfamil | Smaller proteins for easy digestion; DHA for brain support |
Similac 360 Total Care Sensitive Infant Formula

Similac 360 Total Care Sensitive is formulated for fussiness and gas due to lactose sensitivity. Its exclusive blend of 5 HMOs mirrors components found in breast milk to support digestive health. The formula is designed to ease tummy troubles and is marketed toward infants who experience gas or discomfort after feeds, making it a practical option for parents seeking gentle digestion guidance without sacrificing essential nutrients.
Similac 360 Total Care Sensitive Ready-to-Feed

This ready-to-feed option provides the same 5-HMO prebiotic blend, focusing on fussiness and gas linked to lactose sensitivity. It’s convenient for caregivers who prefer pre-measured, ready-to-use formula for quick feeding on the go, while continuing to support infant gut health and digestion.
ByHeart Organic Whole Milk Infant Formula

ByHeart formula is organic and uses a patented protein blend intended to approximate breast milk’s composition. It emphasizes organic whole milk as the base, aligning with parents seeking organic ingredients. Clinical notes point to benefits like easier digestion in some infants and softer stools, with a focus on providing a closest-to-breast-milk experience in a powder formula.
Enfamil Gentlease Easy to Digest

Enfamil Gentlease is designed for easy digestion with gentle proteins aimed at reducing fussiness and gas. It is clinically shown to help ease digestive discomfort and is commonly recommended for babies with sensitive stomachs. The formula also includes nutrients such as DHA and choline to support brain development, offering a dual focus on comfort and development.
Enfamil NeuroPro Gentlease

Enfamil NeuroPro Gentlease combines gentle proteins with NeuroPro DHA and HuMo6 immune blend to support brain development while addressing fussiness, gas, and spit-up. The smaller-protein approach aims to ease digestion within 24 hours for many infants, offering a balance between comfort and cognitive nutrition.
Buying Guide: Key Considerations For Choosing A Formula For Gassy Babies
- Lactose sensitivity and tolerance: Some formulas are specifically designed to be easier on lactose-sensitive tummies or use partially digested proteins to reduce fussiness and gas.
- Protein type and digestibility: Gentler proteins or hydrolyzed protein options can help babies who struggle with standard protein formulations.
- Prebiotics and HMOs: Look for formulas that include human milk oligosaccharides (HMOs) or prebiotic blends, which may support healthy digestion and gut microbiota.
- DHA, choline, and brain support: Many formulas include DHA and lutein; some emphasize brain development alongside digestive comfort.
- Organic and clean-label options: If organic ingredients are a priority, ByHeart and similar brands may align with those preferences.
- Convenience and form: Ready-to-feed formulas offer quick preparation, while powders are cost-efficient and customizable for meal sizes.
- Certification and dietary notes: Kosher, halal, or non-GMO claims may influence choice based on family needs and beliefs.
- Medical guidance: If a baby experiences persistent fussiness, gas, or spit-up, consult a pediatrician to assess potential sensitivities or intolerance and to discuss possible transition strategies.