Yes—22 calorie baby formulas are designed to support growth in specific infant needs, including premature or catch-up growth scenarios. This guide highlights five suitable options, focusing on who they’re best for and why each stands out. The top picks balance growth potential, convenience, and readiness for caregivers seeking higher-calorie formulas without specialized equipment.
Summary table of chosen products:
| Product | Best For | Key Benefit |
|---|---|---|
| Similac NeoSure Premature Post-Discharge Infant Formula (22.8 oz, Pack of 4) | Premature infants post-discharge | Supports better gains in weight, length, and head circumference |
| Similac NeoSure Premature Post-Discharge Infant Formula (13.1 oz, Pack of 6) | Smaller households, ongoing post-discharge support | Committed catch-up growth support |
| Similac NeoSure Premature Post-Discharge Infant Formula (13.1 oz) | Newly discharged preterm babies | Catch-up growth benefits |
| Enfamil NeuroPro Infant Formula | Brain development focus | MFGM and DHA for early cognitive support |
| Enfamil NeuroPro Baby Formula | Longer-term brain and cognitive support | 5-year brain benefit with MFGM/DHA |
Similac NeoSure Premature Post-Discharge Formula (22.8 oz, Pack of 4)

This formula is formulated for premature infants after hospital discharge. It emphasizes catch-up growth and is produced by the same company that leads NICU nutrition. Best for caregivers seeking a proven option with strong post-discharge growth support for weight, length, and head circumference gains compared to standard term formulas.
- Best for: Premature babies needing post-discharge nutrition support
- Why selected: Offers targeted growth gains and NICU lineage
- Limitation: Larger can size may be less convenient for small households
Similac NeoSure Premature Post-Discharge 13.1 oz (Pack of 6)

Designed for post-discharge care in premature infants, this option provides reliable catch-up growth while offering a smaller can size suitable for steady feeding routines. Best for households that prefer a steady supply without frequent bulk purchases.
- Best for: Smaller households needing regular post-discharge support
- Why selected: Consistent growth support with NICU-aligned formulation
- Limitation: Smaller can may increase replacement frequency
Similac NeoSure Premature Post-Discharge 13.1 oz

This variant mirrors the NeoSure post-discharge profile with a 13.1-ounce size. It supports catch-up growth in premature infants and is suitable for families who want to balance calorie density with reasonable can size for daily use.
- Best for: Post-discharge preterm infants needing steady growth
- Why selected: Reliable, NICU-backed growth profile
- Limitation: Limited packaging in some regions may affect availability
Enfamil NeuroPro Infant Formula

This brain-building formula blends DHA with MFGM components, aligning with expert-recommended nutrients found in breast milk. It supports brain development during the baby’s first year and offers ready-to-feed and powder options for caregiver convenience.
- Best for: Families prioritizing early cognitive development
- Why selected: Clinically associated with brain and cognitive development benefits
- Limitation: Some caregivers may prefer a blend closer to breast milk amino-acid profile
Enfamil NeuroPro Baby Formula

Enfamil NeuroPro Baby Formula centers on brain-building nutrients, featuring MFGM and DHA to support development through the first year. It is a solid option for families seeking broad brain-supportive ingredients with a familiar powder variant.
- Best for: Ongoing brain support through the first year
- Why selected: Long-term cognitive development potential
- Limitation: Slightly larger 20.7 oz size may affect storage for some households
Similac 360 Total Care Sensitive (5 HMO Prebiotics)

Targeted for fussiness and gas due to lactose sensitivity, this variant includes prebiotics and is available in ready-to-feed bottles for convenience. Best for babies with sensitive digestion while maintaining essential nutrients.
- Best for: Fussiness or gas from lactose sensitivity
- Why selected: Prebiotic blend supports digestion and comfort
- Limitation: Ready-to-feed format may be less economical per ounce
Similac 360 Total Care Infant Formula

Designed to closely resemble breast milk, this formula includes five HMOs prebiotics and is suitable for families seeking a balanced daily option. It is available in a large tub for ongoing use and provides a broad nutrient profile.
- Best for: Everyday nutrition with prebiotic support
- Why selected: Closest to breast milk among the line
- Limitation: Not specialized for premature post-discharge needs
Buying Guide: Key Purchase Considerations
- Who needs a higher-calorie formula: Premature or catch-up growth babies benefit from formulas designed for post-discharge growth. Look for terms like NeoSure or post-discharge formulations.
- Calorie density and readiness: Calorie-rich options can help with weight gain, but consider your baby’s feeding style (ready-to-feed vs. powder) and convenience for caregivers.
- Brain development focus: If cognitive development is a priority, formulas with DHA and MFGM components are relevant. Compare DHA levels and MFGM presence when possible.
- Digestive comfort: If lactose sensitivity or fussiness is a concern, choose formulas with hypoallergenic signals or added prebiotics that support gut health.
- Package size and storage: Larger cans reduce switching frequency but require more storage space. Choose sizes that fit your routine and household needs.
- Availability and substitutions: Some variants are region-specific. Check local availability and consider safety margins for supply continuity.
FAQ
- What is the main purpose of 22 calorie infant formula?
– It provides higher energy density to support growth, particularly for premature or catch-up scenarios after NICU discharge. - Is NeoSure appropriate for all preterm babies?
– NeoSure is specifically marketed for premature post-discharge nutrition; consult a pediatrician to confirm suitability for individual needs. - Can Enfamil NeuroPro support cognitive development?
– NeuroPro includes DHA and MFGM components associated with brain development, but results vary by infant and feeding plan. - Should I choose ready-to-feed or powder?
– Ready-to-feed offers convenience; powder can be more economical but requires proper preparation and sanitation. - Are there formulas best for lactose sensitivity?
– Some formulas are labeled for fussiness or sensitivity; select those with prebiotic blends and consider lactose-free options if advised by a doctor. - How do I decide between NeoSure and Enfamil NeuroPro?
– If post-discharge catch-up growth for a preterm infant is the priority, NeoSure is a focused choice; for broader brain development goals, NeuroPro is a solid option.